Assay Detail
Functional
CHEMBL2434752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition against human A375-S2 cells after 48 hrs by MTT assay
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A375-S2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 7 | - | - |
| IC50 | 7 | 4.70 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 2 | 5.18 |
| CHEMBL2430311 | — | — | 2 | 4.47 |
| CHEMBL2430312 | — | — | 2 | 4.44 |
| CHEMBL2430314 | — | — | 2 | - |
| CHEMBL2430313 | — | — | 2 | - |
| CHEMBL2430310 | — | — | 2 | - |
| CHEMBL2430309 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL2430311 | — | IC50 | = | 34190.0 | nM | 4.47 |
| CHEMBL2430312 | — | IC50 | = | 36440.0 | nM | 4.44 |
| CHEMBL185 | FLUOROURACIL | GI | - | — | - | |
| CHEMBL2430314 | — | GI | - | — | - | |
| CHEMBL2430313 | — | GI | - | — | - | |
| CHEMBL2430312 | — | GI | - | — | - | |
| CHEMBL2430311 | — | GI | - | — | - | |
| CHEMBL2430310 | — | GI | - | — | - | |
| CHEMBL2430309 | — | GI | - | — | - | |
| CHEMBL2430314 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2430313 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2430310 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2430309 | — | IC50 | > | 50000.0 | nM | - |