Assay Detail
Functional
CHEMBL2434754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition against human HT1080 cells after 48 hrs by MTT assay
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 7 | - | - |
| IC50 | 7 | 4.46 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2430309 | — | — | 2 | 4.50 |
| CHEMBL2430311 | — | — | 2 | 4.48 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 2 | 4.45 |
| CHEMBL2430312 | — | — | 2 | 4.45 |
| CHEMBL2430310 | — | — | 2 | 4.44 |
| CHEMBL2430314 | — | — | 2 | - |
| CHEMBL2430313 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2430309 | — | IC50 | = | 31930.0 | nM | 4.50 |
| CHEMBL2430311 | — | IC50 | = | 33020.0 | nM | 4.48 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 35620.0 | nM | 4.45 |
| CHEMBL2430312 | — | IC50 | = | 35220.0 | nM | 4.45 |
| CHEMBL2430310 | — | IC50 | = | 36350.0 | nM | 4.44 |
| CHEMBL185 | FLUOROURACIL | GI | - | — | - | |
| CHEMBL2430314 | — | GI | - | — | - | |
| CHEMBL2430313 | — | GI | - | — | - | |
| CHEMBL2430312 | — | GI | - | — | - | |
| CHEMBL2430311 | — | GI | - | — | - | |
| CHEMBL2430310 | — | GI | - | — | - | |
| CHEMBL2430309 | — | GI | - | — | - | |
| CHEMBL2430314 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2430313 | — | IC50 | > | 50000.0 | nM | - |