Assay Detail
Binding
CHEMBL2437702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2434817) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.02 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2436982 | — | — | 1 | 6.92 |
| CHEMBL2436981 | — | — | 1 | 6.37 |
| CHEMBL2436978 | — | — | 1 | 6.34 |
| CHEMBL2436983 | — | — | 1 | 6.29 |
| CHEMBL2436976 | — | — | 1 | 6.00 |
| CHEMBL2436980 | — | — | 1 | 5.57 |
| CHEMBL2436979 | — | — | 1 | 4.63 |
| CHEMBL2436977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2436982 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2436981 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2436978 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2436983 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2436976 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2436980 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2436979 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL2436977 | — | IC50 | - | — | - |