Assay Detail
Binding
CHEMBL2437703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2436980 | — | — | 1 | 8.52 |
| CHEMBL2436982 | — | — | 1 | 8.15 |
| CHEMBL2436976 | — | — | 1 | 8.05 |
| CHEMBL2436978 | — | — | 1 | 7.85 |
| CHEMBL2436981 | — | — | 1 | 7.72 |
| CHEMBL2436977 | — | — | 1 | 7.68 |
| CHEMBL2436979 | — | — | 1 | 7.40 |
| CHEMBL2436983 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2436980 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2436982 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2436976 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2436978 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2436981 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2436977 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2436979 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2436983 | — | IC50 | = | 78.0 | nM | 7.11 |