Mitogen-activated protein kinase kinase kinase 11 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mitogen-activated protein kinase kinase kinase 11 shows clinical signal disease relevance led by Parkinson disease. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q16584. Start with Parkinson disease, then reuse UniProt Q16584 as the stable protein anchor across project notes and exports.
Start with Parkinson disease, then reuse UniProt Q16584 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase kinase kinase 11 shows clinical signal disease relevance led by Parkinson disease. 1 linked drug remains visible in the same block.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CEP-1347. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase kinase kinase 11
Review this target as Mitogen-activated protein kinase kinase kinase 11, mapped to UniProt Q16584. Sequence length is 847 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 11 as ChEMBL target CHEMBL2708, mapped to UniProt Q16584. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mitogen-activated protein kinase kinase kinase 11 is the right protein anchor across sources, using UniProt Q16584 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Parkinson disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 11 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16584 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 11 |
| UniProt Accession | Q16584 |
| Component Type | Protein |
| Sequence Length | 847 aa |
Mitogen-activated protein kinase kinase kinase 11
Review this target as Mitogen-activated protein kinase kinase kinase 11, mapped to UniProt Q16584. Sequence length is 847 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase kinase kinase 11 shows clinical signal disease relevance led by Parkinson disease.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CEP-1347. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 8.61 | IC50 | 2.47 | Preclinical |
| CHEMBL2436980 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4465866 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL4576489 | 8.4 | Kd | 4.0 | Preclinical |
| CHEMBL281948 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL290352 | 8.22 | IC50 | 6.0 | Clinical |
| CHEMBL5397520 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5403058 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL2436982 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL4218417 | 8.15 | IC50 | 7.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 194 | 163 | 6.5 |
| cell-based format | 30 | 5 | 8.1 |
| subcellular format | 26 | 39 | 6.0 |
| assay format | 23 | 19 | 7.1 |