Assay Detail
Binding
CHEMBL2438375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from sigma 2 receptor in Wistar Hannover rat liver membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.02 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437383 | — | — | 1 | 8.45 |
| CHEMBL2437387 | — | — | 1 | 8.37 |
| CHEMBL2437384 | — | — | 1 | 8.24 |
| CHEMBL2437386 | — | — | 1 | 8.03 |
| CHEMBL2437385 | — | — | 1 | 7.79 |
| CHEMBL2437382 | — | — | 1 | 7.70 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437383 | — | Ki | = | 3.56 | nM | 8.45 |
| CHEMBL2437387 | — | Ki | = | 4.24 | nM | 8.37 |
| CHEMBL2437384 | — | Ki | = | 5.74 | nM | 8.24 |
| CHEMBL2437386 | — | Ki | = | 9.24 | nM | 8.03 |
| CHEMBL2437385 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL2437382 | — | Ki | = | 20.1 | nM | 7.70 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 25.7 | nM | 7.59 |