Compound Detail
CHEMBL2437384
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Basic Information
| ChEMBL ID | CHEMBL2437384 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KWESVLHDFRAQRS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.5
MW (Da)
3.16
ALogP
5
HBA
0
HBD
51.2
PSA (Ų)
0.70
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 8.24 | 8.24 | 5.7 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 6.4 | 6.4 | 402.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 5.74 | nM | 8.24 | Displacement of [3H]-DTG from sigma 2 receptor in Wistar Hannover rat liver memb... | 24161678 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 402.0 | nM | 6.4 | Displacement of (+)-[3H]-pentazocine from sigma 1 receptor in Dunkin guinea pig ... | 24161678 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24161678 | 10.1016/j.ejmech.2013.09.018 | Unchecked | 2 |
| 24161678 | 10.1016/j.ejmech.2013.09.018 | Sigma non-opioid intracellular receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine