Assay Detail
Functional
CHEMBL2438485
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Cytotoxicity against human HaCaT cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437042 | — | — | 1 | 6.72 |
| CHEMBL2437045 | — | — | 1 | 5.90 |
| CHEMBL2434990 | — | — | 1 | 5.69 |
| CHEMBL2105611 | TACALCITOL | 3.0 | 1 | 5.68 |
| CHEMBL2437043 | — | — | 1 | 5.68 |
| CHEMBL2437025 | — | — | 1 | 5.01 |
| CHEMBL2437041 | — | — | 1 | 4.80 |
| CHEMBL2437053 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437042 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2437045 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2434990 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL2105611 | TACALCITOL | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL2437043 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2437025 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL2437041 | — | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL2437053 | — | IC50 | = | 28890.0 | nM | 4.54 |