Assay Detail
Binding
CHEMBL2438603
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Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.43 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426373 | — | — | 1 | 5.34 |
| CHEMBL2437367 | LICOAGRONE | — | 1 | 5.22 |
| CHEMBL2437368 | LICOAGRODIN | — | 1 | 4.94 |
| CHEMBL2437369 | LICOAGROAURONE | — | 1 | 4.62 |
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 4.56 |
| CHEMBL2437373 | — | — | 1 | 4.49 |
| CHEMBL2437364 | — | — | 1 | 4.44 |
| CHEMBL462721 | GLABROL | — | 1 | 4.43 |
| CHEMBL561840 | — | — | 1 | 4.35 |
| CHEMBL2437377 | — | — | 1 | 4.28 |
| CHEMBL141207 | — | — | 1 | 4.24 |
| CHEMBL2437370 | — | — | 1 | 4.22 |
| CHEMBL256340 | LESPEDEZAFLAVANONE B | — | 1 | 4.21 |
| CHEMBL600457 | GLABRONE | — | 1 | 4.18 |
| CHEMBL469824 | ODORATIN | — | 1 | 4.16 |
| CHEMBL362378 | — | — | 1 | 4.13 |
| CHEMBL480477 | GLABRIDIN | — | 1 | 4.13 |
| CHEMBL463947 | — | — | 1 | 4.12 |
| CHEMBL2437363 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426373 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2437367 | LICOAGRONE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2437368 | LICOAGRODIN | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL2437369 | LICOAGROAURONE | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL253467 | ISOBAVACHALCONE | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL2437373 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL2437364 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL462721 | GLABROL | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL561840 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL2437377 | — | IC50 | = | 52200.0 | nM | 4.28 |
| CHEMBL141207 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL2437370 | — | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL256340 | LESPEDEZAFLAVANONE B | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL600457 | GLABRONE | IC50 | = | 66300.0 | nM | 4.18 |
| CHEMBL469824 | ODORATIN | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL362378 | — | IC50 | = | 74100.0 | nM | 4.13 |
| CHEMBL480477 | GLABRIDIN | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL463947 | — | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL2437363 | — | IC50 | = | 90500.0 | nM | 4.04 |