Assay Detail
Functional
CHEMBL2439211
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Cytotoxicity against human BT474 cells after 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.40 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437226 | — | — | 1 | 7.73 |
| CHEMBL3436359 | — | — | 1 | 7.72 |
| CHEMBL2437224 | — | — | 1 | 7.65 |
| CHEMBL2437227 | — | — | 1 | 7.58 |
| CHEMBL2437225 | — | — | 1 | 7.56 |
| CHEMBL2437223 | — | — | 1 | 7.46 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | 4.0 | 1 | 7.43 |
| CHEMBL3436356 | — | — | 1 | 7.38 |
| CHEMBL3436360 | — | — | 1 | 7.21 |
| CHEMBL3436355 | — | — | 1 | 7.17 |
| CHEMBL3436358 | — | — | 1 | 7.16 |
| CHEMBL3436354 | — | — | 1 | 7.07 |
| CHEMBL3436357 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437226 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL3436359 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL2437224 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2437227 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL2437225 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL2437223 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL3436356 | — | IC50 | = | 41.9 | nM | 7.38 |
| CHEMBL3436360 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL3436355 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL3436358 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3436354 | — | IC50 | = | 84.6 | nM | 7.07 |
| CHEMBL3436357 | — | IC50 | = | 88.1 | nM | 7.05 |