Assay Detail
Functional
CHEMBL2439212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-N87 cells after 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-N87 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.34 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437226 | — | — | 1 | 7.88 |
| CHEMBL3436359 | — | — | 1 | 7.61 |
| CHEMBL3436356 | — | — | 1 | 7.54 |
| CHEMBL2437224 | — | — | 1 | 7.53 |
| CHEMBL2437225 | — | — | 1 | 7.48 |
| CHEMBL3436355 | — | — | 1 | 7.37 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | 4.0 | 1 | 7.33 |
| CHEMBL2437223 | — | — | 1 | 7.33 |
| CHEMBL2437227 | — | — | 1 | 7.29 |
| CHEMBL3436354 | — | — | 1 | 7.20 |
| CHEMBL3436358 | — | — | 1 | 7.14 |
| CHEMBL3436357 | — | — | 1 | 7.01 |
| CHEMBL3436360 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437226 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL3436359 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL3436356 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL2437224 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL2437225 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL3436355 | — | IC50 | = | 42.8 | nM | 7.37 |
| CHEMBL1201179 | LAPATINIB DITOSYLATE | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL2437223 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL2437227 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL3436354 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL3436358 | — | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL3436357 | — | IC50 | = | 97.7 | nM | 7.01 |
| CHEMBL3436360 | — | IC50 | = | 204.8 | nM | 6.69 |