Assay Detail
Functional
CHEMBL2443622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTT assay
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and anticancer activity of analogs of the indole phytoalexins brassinin, 1-methoxyspirobrassinol methyl ether and cyclobrassinin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 4.82 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL2442564 | — | — | 1 | 5.77 |
| CHEMBL2442585 | — | — | 1 | 5.54 |
| CHEMBL2442584 | — | — | 1 | 5.46 |
| CHEMBL2442578 | — | — | 1 | 5.42 |
| CHEMBL2442580 | — | — | 1 | 5.42 |
| CHEMBL2442583 | — | — | 1 | 5.42 |
| CHEMBL2442573 | — | — | 1 | 5.41 |
| CHEMBL2442572 | — | — | 1 | 5.33 |
| CHEMBL2442595 | — | — | 1 | 5.30 |
| CHEMBL2442568 | — | — | 1 | 5.30 |
| CHEMBL2442567 | — | — | 1 | 5.30 |
| CHEMBL2442549 | — | — | 1 | 5.29 |
| CHEMBL2440143 | — | — | 1 | 5.23 |
| CHEMBL2442574 | — | — | 1 | 5.18 |
| CHEMBL2442543 | — | — | 1 | 5.17 |
| CHEMBL2442588 | — | — | 1 | 5.16 |
| CHEMBL2442542 | — | — | 1 | 5.14 |
| CHEMBL2442570 | — | — | 1 | 5.12 |
| CHEMBL2442562 | — | — | 1 | 5.05 |
| CHEMBL2442569 | — | — | 1 | 5.00 |
| CHEMBL2442579 | — | — | 1 | 4.92 |
| CHEMBL2442593 | — | — | 1 | 4.91 |
| CHEMBL2442598 | — | — | 1 | 4.84 |
| CHEMBL2442539 | — | — | 1 | 4.84 |
| CHEMBL2442582 | — | — | 1 | 4.80 |
| CHEMBL2442544 | — | — | 1 | 4.76 |
| CHEMBL2442541 | — | — | 1 | 4.74 |
| CHEMBL2442545 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2442564 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2442585 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2442584 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2442578 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2442580 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2442583 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2442573 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2442572 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2442595 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2442568 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2442567 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2442549 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2440143 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2442574 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2442543 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2442588 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2442542 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2442570 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2442562 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2442569 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2442579 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2442593 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL2442539 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2442598 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL2442582 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2442544 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL2442541 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL2442545 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL2442540 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2442600 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2442576 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL2442581 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2442594 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2442560 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL2442538 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL2442546 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL2442551 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL2442599 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL2442561 | CYCLOBRASSININ | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL2442597 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2442557 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL2442571 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2442550 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL2442565 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL2442552 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL2442556 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL2442558 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2442554 | — | IC50 | = | 35900.0 | nM | 4.45 |