Assay Detail
Functional
CHEMBL2443692
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Inhibition of LPS-induced TNFalpha production in Balb/c mouse splenocytes after 18 to 24 hrs by AlphaLISA assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.45 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442465 | — | — | 1 | 9.68 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 8.92 |
| CHEMBL2442472 | — | — | 1 | 8.52 |
| CHEMBL2442462 | — | — | 1 | 8.42 |
| CHEMBL2442461 | — | — | 1 | 8.15 |
| CHEMBL2442479 | — | — | 1 | 8.02 |
| CHEMBL2442470 | — | — | 1 | 7.92 |
| CHEMBL2442469 | — | — | 1 | 7.75 |
| CHEMBL2442475 | — | — | 1 | 7.64 |
| CHEMBL2442473 | — | — | 1 | 7.37 |
| CHEMBL2442468 | — | — | 1 | 7.33 |
| CHEMBL2442471 | — | — | 1 | 7.31 |
| CHEMBL2442467 | — | — | 1 | 7.13 |
| CHEMBL2442464 | — | — | 1 | 6.34 |
| CHEMBL2442480 | — | — | 1 | 6.16 |
| CHEMBL2442478 | — | — | 1 | 6.08 |
| CHEMBL2442477 | — | — | 1 | 6.00 |
| CHEMBL2442474 | — | — | 1 | 5.32 |
| CHEMBL2440142 | — | — | 1 | - |
| CHEMBL2442476 | — | — | 1 | - |
| CHEMBL2442463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442465 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2442472 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2442462 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2442461 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2442479 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL2442470 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2442469 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2442475 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2442473 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2442468 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2442471 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2442467 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2442464 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2442480 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2442478 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL2442477 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2442474 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2440142 | — | IC50 | - | — | - | |
| CHEMBL2442476 | — | IC50 | - | — | - | |
| CHEMBL2442463 | — | IC50 | - | — | - |