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Assay Detail

CHEMBL2443738

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Functional
Cytotoxicity against human MT4 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.
Spallarossa A, Rotolo C, Sissi C, Marson G, Greco ML, Ranise A, La Colla P, Busonera B, Loddo R.
Bioorg Med Chem (2013) 21 : 6328 -6336
PubMed 24063907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.38 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2443293 1 5.80
CHEMBL2443292 1 5.77
CHEMBL2443294 1 5.77
CHEMBL2443295 1 5.70
CHEMBL2443298 1 5.62
CHEMBL2440361 1 5.60
CHEMBL1996291 1 5.48
CHEMBL2443286 1 5.44
CHEMBL2443296 1 5.16
CHEMBL2443301 1 5.10
CHEMBL2443299 1 5.10
CHEMBL2440360 1 5.08
CHEMBL1765797 MERBARONE 1 4.92
CHEMBL2443300 1 4.80
CHEMBL2443297 1 -
CHEMBL2440358 1 -
CHEMBL2440359 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2443293 IC50 = 1600.0 nM 5.80
CHEMBL2443292 IC50 = 1700.0 nM 5.77
CHEMBL2443294 IC50 = 1700.0 nM 5.77
CHEMBL2443295 IC50 = 2000.0 nM 5.70
CHEMBL2443298 IC50 = 2400.0 nM 5.62
CHEMBL2440361 IC50 = 2500.0 nM 5.60
CHEMBL1996291 IC50 = 3300.0 nM 5.48
CHEMBL2443286 IC50 = 3600.0 nM 5.44
CHEMBL2443296 IC50 = 7000.0 nM 5.16
CHEMBL2443301 IC50 = 8000.0 nM 5.10
CHEMBL2443299 IC50 = 8000.0 nM 5.10
CHEMBL2440360 IC50 = 8400.0 nM 5.08
CHEMBL1765797 MERBARONE IC50 = 12000.0 nM 4.92
CHEMBL2443300 IC50 = 16000.0 nM 4.80
CHEMBL2443297 IC50 > 100000.0 nM -
CHEMBL2440358 IC50 > 100000.0 nM -
CHEMBL2440359 IC50 > 100000.0 nM -