Assay Detail
Binding
CHEMBL2443948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 2-alpha kinase 1 (CHEMBL6029) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441342 | — | — | 1 | 7.43 |
| CHEMBL2441346 | — | — | 1 | 7.21 |
| CHEMBL2441340 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441342 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2441346 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2441340 | — | IC50 | = | 460.0 | nM | 6.34 |