Eukaryotic translation initiation factor 2-alpha kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9BQI3. Use UniProt Q9BQI3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9BQI3 as the stable identity anchor, then attach disease evidence before program review.
Eukaryotic translation initiation factor 2-alpha kinase 1
Review this target as Eukaryotic translation initiation factor 2-alpha kinase 1, mapped to UniProt Q9BQI3. Sequence length is 630 aa.
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This review treats Eukaryotic translation initiation factor 2-alpha kinase 1 as ChEMBL target CHEMBL6029, mapped to UniProt Q9BQI3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Eukaryotic translation initiation factor 2-alpha kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9BQI3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Eukaryotic translation initiation factor 2-alpha kinase 1 |
| UniProt Accession | Q9BQI3 |
| Component Type | Protein |
| Sequence Length | 630 aa |
Eukaryotic translation initiation factor 2-alpha kinase 1
Review this target as Eukaryotic translation initiation factor 2-alpha kinase 1, mapped to UniProt Q9BQI3. Sequence length is 630 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL573760 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL578426 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL576168 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL4281823 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL574005 | 7.5 | IC50 | 31.62 | Preclinical |
| CHEMBL2441342 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL578836 | 7.3 | IC50 | 50.12 | Preclinical |
| CHEMBL428690 | 7.24 | Kd | 58.0 | Clinical |
| CHEMBL2441346 | 7.21 | IC50 | 61.0 | Preclinical |
| CHEMBL574443 | 7.2 | IC50 | 63.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 81 | 44 | 6.4 |
| cell-based format | 21 | 0 | — |
| assay format | 20 | 0 | — |
| subcellular format | 1 | 16 | 5.9 |