Compound Detail
CHEMBL578836
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL578836 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JLPAFVDLGBDXBM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
339.8
MW (Da)
4.56
ALogP
3
HBA
2
HBD
49.9
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 2-alpha kinase 1 CHEMBL6029 | IC50 | 7.3 | 7.3 | 50.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 2-alpha kinase 1 | IC50 | = | 50.12 | nM | 7.3 | Inhibition of human HRI kinase | 19854648 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19854648 | 10.1016/j.bmcl.2009.10.033 | Eukaryotic translation initiation factor 2-alpha kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine