Compound Detail
CHEMBL576168
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Basic Information
| ChEMBL ID | CHEMBL576168 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PVHDDOYSCSRNHC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
369.9
MW (Da)
4.57
ALogP
4
HBA
2
HBD
59.2
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 2-alpha kinase 1 CHEMBL6029 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 2-alpha kinase 1 | IC50 | = | 19.95 | nM | 7.7 | Inhibition of human HRI kinase | 19854648 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19854648 | 10.1016/j.bmcl.2009.10.033 | Eukaryotic translation initiation factor 2-alpha kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine