Assay Detail
Binding
CHEMBL2444040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK2 (unknown origin) using long S6 kinase peptide as substrate by radiometric assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.04 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2440742 | — | — | 1 | 8.92 |
| CHEMBL2440735 | — | — | 1 | 8.85 |
| CHEMBL2440745 | — | — | 1 | 8.85 |
| CHEMBL2440733 | — | — | 1 | 8.82 |
| CHEMBL2440737 | — | — | 1 | 8.60 |
| CHEMBL2440730 | — | — | 1 | 8.57 |
| CHEMBL2440743 | — | — | 1 | 8.54 |
| CHEMBL2440732 | — | — | 1 | 8.44 |
| CHEMBL2440756 | — | — | 1 | 8.37 |
| CHEMBL2440747 | — | — | 1 | 8.31 |
| CHEMBL2440753 | — | — | 1 | 8.30 |
| CHEMBL2440750 | — | — | 1 | 8.29 |
| CHEMBL2440746 | — | — | 1 | 8.26 |
| CHEMBL2440752 | — | — | 1 | 8.21 |
| CHEMBL2440749 | — | — | 1 | 8.11 |
| CHEMBL2440736 | — | — | 1 | 8.06 |
| CHEMBL2440738 | — | — | 1 | 7.92 |
| CHEMBL2440755 | — | — | 1 | 7.89 |
| CHEMBL2440751 | — | — | 1 | 7.70 |
| CHEMBL2440748 | — | — | 1 | 7.66 |
| CHEMBL2440734 | — | — | 1 | 7.43 |
| CHEMBL2440731 | — | — | 1 | 7.35 |
| CHEMBL2440754 | — | — | 1 | 7.32 |
| CHEMBL559147 | Y-27632 | — | 1 | 7.27 |
| CHEMBL2440740 | — | — | 1 | 7.26 |
| CHEMBL2440741 | — | — | 1 | 6.99 |
| CHEMBL2440739 | — | — | 1 | 6.78 |
| CHEMBL2440744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2440742 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2440735 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2440745 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2440733 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2440737 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2440730 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2440743 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2440732 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2440756 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2440747 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2440753 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2440750 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2440746 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2440752 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL2440749 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL2440736 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2440738 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2440755 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2440751 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2440748 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2440734 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2440731 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2440754 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL559147 | Y-27632 | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2440740 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2440741 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2440739 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL2440744 | — | IC50 | < | 1.0 | nM | - |