Compound Detail
CHEMBL2440740
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Basic Information
| ChEMBL ID | CHEMBL2440740 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IGQRXPNMALPSCN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
365.4
MW (Da)
3.30
ALogP
4
HBA
3
HBD
105.3
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 7.26 | 7.26 | 55.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 2.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | IC50 | = | 55.0 | nM | 7.26 | Inhibition of ROCK2 (unknown origin) using long S6 kinase peptide as substrate b... | 24119557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24119557 | 10.1016/j.bmcl.2013.09.040 | Plasma | 2 |
| 24119557 | 10.1016/j.bmcl.2013.09.040 | ADMET | 1 |
| 24119557 | 10.1016/j.bmcl.2013.09.040 | Unchecked | 1 |
| 24119557 | 10.1016/j.bmcl.2013.09.040 | Rho-associated protein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine