Assay Detail
Functional
CHEMBL2444378
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Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay
22
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.54 | 5.17 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441912 | — | — | 1 | 5.17 |
| CHEMBL133491 | — | — | 1 | 5.03 |
| CHEMBL2441914 | — | — | 1 | 4.85 |
| CHEMBL2441911 | — | — | 1 | 4.69 |
| CHEMBL2441917 | — | — | 1 | 4.68 |
| CHEMBL2441913 | — | — | 1 | 4.68 |
| CHEMBL131982 | — | — | 1 | 4.58 |
| CHEMBL2441916 | — | — | 1 | 4.47 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.47 |
| CHEMBL490372 | — | — | 1 | 4.34 |
| CHEMBL29489 | BUTYL CAFFEATE | — | 1 | 4.34 |
| CHEMBL133714 | BENZYL CAFFEATE | — | 1 | 4.34 |
| CHEMBL2441915 | — | — | 1 | 4.33 |
| CHEMBL481890 | — | — | 1 | 4.29 |
| CHEMBL17362 | — | — | 1 | 4.22 |
| CHEMBL471973 | — | — | 1 | 4.18 |
| CHEMBL67498 | CAFFEIC ACID PHENETHYL AMIDE | — | 1 | - |
| CHEMBL17347 | ETHYL CAFFEATE | — | 2 | - |
| CHEMBL17001 | METHYLCAFFEATE | — | 2 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441912 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL133491 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2441914 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2441911 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL2441913 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL2441917 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL131982 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL2441916 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL133714 | BENZYL CAFFEATE | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL490372 | — | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL29489 | BUTYL CAFFEATE | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL2441915 | — | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL481890 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL17362 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL471973 | — | IC50 | = | 65900.0 | nM | 4.18 |
| CHEMBL67498 | CAFFEIC ACID PHENETHYL AMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL17347 | ETHYL CAFFEATE | Activity | - | — | - | |
| CHEMBL17001 | METHYLCAFFEATE | Activity | - | — | - | |
| CHEMBL17347 | ETHYL CAFFEATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL17001 | METHYLCAFFEATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | > | 100000.0 | nM | - |