Assay Detail

CHEMBL2444558

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Binding

Displacement of [3H]-prostaglandin D2 from mouse CRTh2 receptor expressed in CHO cells after 2 hrs

ChEMBL ↗

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Target

Prostaglandin D2 receptor 2 (CHEMBL2291) ↗

Open DB target context

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Prostaglandin D2 receptor 2 (CHEMBL2291) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin D2 receptor 2

CHEMBL2291

Anchored from Assay target.

Protein identity Prostaglandin D2 receptor 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Cell Type	CHO
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin D2 receptor 2 (CHEMBL2291) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.

Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C.
Bioorg Med Chem (2013) 21 : 6582 -6591
PubMed 24021582 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.00	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2442750	QAV680	2.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2442750	QAV680	Ki	=	10.0	nM	8.00