Assay Detail
Functional
CHEMBL2444683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against BCR-ABL fusion protein 190 expressing mouse bone marrow cells after 72 hrs by vital dye exclusion/flow cytometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.50 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441554 | — | — | 1 | 6.30 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.48 |
| CHEMBL2441553 | — | — | 1 | 5.40 |
| CHEMBL2441555 | — | — | 1 | 5.24 |
| CHEMBL2441552 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441554 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2441553 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2441555 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2441552 | — | IC50 | = | 8400.0 | nM | 5.08 |