Assay Detail
Functional
CHEMBL2444688
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Cytotoxicity against Ph-negative human CCRF-CEM cells after 72 hrs by vital dye exclusion/flow cytometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.05 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.17 |
| CHEMBL2441553 | — | — | 1 | 5.09 |
| CHEMBL2441554 | — | — | 1 | 5.09 |
| CHEMBL2441555 | — | — | 1 | 4.96 |
| CHEMBL2441552 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2441553 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2441554 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2441555 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2441552 | — | IC50 | = | 11600.0 | nM | 4.94 |