Assay Detail
Binding
CHEMBL2445017
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Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis in presence of maltose neopentyl glycol
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.01 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441619 | — | — | 1 | 7.41 |
| CHEMBL2335165 | — | — | 1 | 7.14 |
| CHEMBL236696 | — | — | 1 | 7.12 |
| CHEMBL1892158 | — | — | 1 | 7.08 |
| CHEMBL2441621 | — | — | 1 | 6.46 |
| CHEMBL2441616 | — | — | 1 | 5.75 |
| CHEMBL2441615 | — | — | 1 | 5.10 |
| CHEMBL2441617 | — | — | 1 | 4.17 |
| CHEMBL339069 | — | — | 1 | 3.85 |
| CHEMBL2441618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441619 | — | Kd | = | 39.0 | nM | 7.41 |
| CHEMBL2335165 | — | Kd | = | 72.5 | nM | 7.14 |
| CHEMBL236696 | — | Kd | = | 76.5 | nM | 7.12 |
| CHEMBL1892158 | — | Kd | = | 84.2 | nM | 7.08 |
| CHEMBL2441621 | — | Kd | = | 348.3 | nM | 6.46 |
| CHEMBL2441616 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL2441615 | — | Kd | = | 8000.0 | nM | 5.10 |
| CHEMBL2441617 | — | Kd | = | 67100.0 | nM | 4.17 |
| CHEMBL339069 | — | Kd | = | 141600.0 | nM | 3.85 |
| CHEMBL2441618 | — | Kd | - | — | - |