Assay Detail
Binding
CHEMBL2445161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in CD1 mouse brain membranes after 1 hr by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.17 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | 3.0 | 1 | 8.92 |
| CHEMBL2442642 | — | — | 1 | 5.24 |
| CHEMBL2442643 | — | — | 1 | 5.13 |
| CHEMBL2442641 | — | — | 1 | 5.12 |
| CHEMBL426912 | — | — | 1 | 5.09 |
| CHEMBL2442635 | — | — | 1 | 5.09 |
| CHEMBL2442645 | — | — | 1 | 5.05 |
| CHEMBL2442637 | — | — | 1 | 4.89 |
| CHEMBL2442638 | — | — | 1 | 4.54 |
| CHEMBL2442639 | — | — | 1 | 4.38 |
| CHEMBL2442640 | — | — | 1 | 4.29 |
| CHEMBL2442636 | — | — | 1 | 4.28 |
| CHEMBL2442644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2442642 | — | Ki | = | 5750.0 | nM | 5.24 |
| CHEMBL2442643 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL2442641 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL426912 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL2442635 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL2442645 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL2442637 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL2442638 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL2442639 | — | Ki | = | 41500.0 | nM | 4.38 |
| CHEMBL2442640 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL2442636 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL2442644 | — | Ki | > | 50000.0 | nM | - |