Assay Detail
Binding
CHEMBL2446194
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Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.33 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 9.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.98 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 11.0 | nM | 7.96 |