Assay Detail
Binding
CHEMBL2446445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at androgen receptor H874Y mutant (unknown origin) expressed in human 22Rv1 cells assessed as inhibition of DHT-induced cell growth after 3 days by WST-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.90 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441094 | — | — | 1 | 6.66 |
| CHEMBL2441092 | — | — | 1 | 5.89 |
| CHEMBL2441107 | — | — | 1 | 5.72 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441094 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2441092 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2441107 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 4600.0 | nM | 5.34 |