Assay Detail
Functional
CHEMBL2446513
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Cytotoxicity against human H460 cells after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.48 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463165 | — | — | 1 | 5.58 |
| CHEMBL2443311 | — | — | 1 | 5.07 |
| CHEMBL486598 | EVODIAMINE | — | 1 | 4.88 |
| CHEMBL2443305 | — | — | 1 | 4.62 |
| CHEMBL2443304 | — | — | 1 | 4.46 |
| CHEMBL2443310 | — | — | 1 | 4.31 |
| CHEMBL2443308 | — | — | 1 | 4.28 |
| CHEMBL2443303 | — | — | 1 | 4.26 |
| CHEMBL2443208 | — | — | 1 | 4.23 |
| CHEMBL2443306 | — | — | 1 | 4.22 |
| CHEMBL2443302 | — | — | 1 | 4.18 |
| CHEMBL2443312 | — | — | 1 | 4.14 |
| CHEMBL2443209 | — | — | 1 | 4.06 |
| CHEMBL2443210 | — | — | 1 | - |
| CHEMBL2443309 | — | — | 1 | - |
| CHEMBL2443307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463165 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2443311 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL486598 | EVODIAMINE | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2443305 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2443304 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2443310 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL2443308 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL2443303 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL2443208 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL2443306 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL2443302 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL2443312 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL2443209 | — | IC50 | = | 86800.0 | nM | 4.06 |
| CHEMBL2443210 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2443309 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2443307 | — | IC50 | > | 30000.0 | nM | - |