Assay Detail
Functional
CHEMBL2446539
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Antiviral activity against Hepatitis C virus infected in human HuH7 cells assessed as viral RNA replication
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 19 | - | - |
| EC50 | 19 | 5.86 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | 4.0 | 2 | 8.00 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 2 | 6.40 |
| CHEMBL2441766 | — | — | 2 | 6.16 |
| CHEMBL2441768 | — | — | 2 | 6.10 |
| CHEMBL2441773 | — | — | 2 | 5.64 |
| CHEMBL2441774 | — | — | 2 | 5.27 |
| CHEMBL2441763 | — | — | 2 | 5.24 |
| CHEMBL2441762 | — | — | 2 | 5.05 |
| CHEMBL2441775 | — | — | 2 | 4.89 |
| CHEMBL2441764 | — | — | 2 | - |
| CHEMBL2441767 | — | — | 2 | - |
| CHEMBL2441778 | — | — | 2 | - |
| CHEMBL2441769 | — | — | 2 | - |
| CHEMBL2441770 | — | — | 2 | - |
| CHEMBL2441771 | — | — | 2 | - |
| CHEMBL2441772 | — | — | 2 | - |
| CHEMBL2441765 | — | — | 2 | - |
| CHEMBL2441776 | — | — | 2 | - |
| CHEMBL2441777 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2441766 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2441768 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2441773 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2441774 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2441763 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2441762 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2441775 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2441777 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL218394 | BOCEPREVIR | EC90 | = | 0.03 | uM | - |
| CHEMBL2441776 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441775 | — | EC90 | = | 31.0 | uM | - |
| CHEMBL2441774 | — | EC90 | = | 9.7 | uM | - |
| CHEMBL2441773 | — | EC90 | = | 6.4 | uM | - |
| CHEMBL2441765 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441771 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441770 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441769 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441768 | — | EC90 | = | 1.5 | uM | - |
| CHEMBL2441767 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441766 | — | EC90 | = | 1.0 | uM | - |
| CHEMBL231813 | TELAPREVIR | EC90 | = | 0.9 | uM | - |
| CHEMBL2441778 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441762 | — | EC90 | = | 30.0 | uM | - |
| CHEMBL2441763 | — | EC90 | = | 9.8 | uM | - |
| CHEMBL2441764 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441772 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL2441767 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441769 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441770 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441771 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441772 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441776 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441777 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441778 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441765 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2441764 | — | EC50 | > | 10000.0 | nM | - |