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Compound Detail

CHEMBL2441775

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CCCC(NC(=O)C1N(C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)CC12Cc1ccccc1C2)C(=O)C(=O)NC1CC1

Basic Information

ChEMBL ID CHEMBL2441775
Phase Preclinical
Structure Type MOL
InChI Key FUOWEQDGPVOGIU-KWKWTDQQSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

581.8
MW (Da)
2.63
ALogP
5
HBA
4
HBD
136.7
PSA (Ų)
0.33
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H47N5O5
MW 581.76
Aromatic Rings 1
Heavy Atoms 42
NP-Likeness -0.26

Activity Summary

EC50 1 meas. best 4.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 4.89 4.89 13000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hepatitis C virus EC50 = 13000.0 nM 4.89 Antiviral activity against Hepatitis C virus infected in human HuH7 cells assess... 24135727

Literature References

Data from ChEMBL 36 via Core Engine