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Assay Detail

CHEMBL2446674

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at androgen receptor in mouse SC3 cells assessed as inhibition of DHT-induced cell growth after 3 days by CCK-8/WST-8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type SC-3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL3056)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.
Yamada A, Fujii S, Mori S, Kagechika H.
ACS Med Chem Lett (2013) 4 : 937 -941
PubMed 24900588 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.42 6.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL491 HYDROXYFLUTAMIDE 2.0 1 6.43
CHEMBL2441094 1 6.12
CHEMBL2441107 1 5.70
CHEMBL2441092 1 5.54
CHEMBL2441100 1 5.52
CHEMBL2441091 1 5.23
CHEMBL2441098 1 5.17
CHEMBL2441093 1 5.14
CHEMBL2441105 1 5.06
CHEMBL2441099 1 5.06
CHEMBL2441110 1 5.03
CHEMBL2441097 1 5.01
CHEMBL2441101 1 -
CHEMBL2441103 1 -
CHEMBL2441102 1 -
CHEMBL2441108 1 -
CHEMBL2441095 1 -
CHEMBL2441109 1 -
CHEMBL2441096 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL491 HYDROXYFLUTAMIDE IC50 = 370.0 nM 6.43
CHEMBL2441094 IC50 = 750.0 nM 6.12
CHEMBL2441107 IC50 = 2000.0 nM 5.70
CHEMBL2441092 IC50 = 2900.0 nM 5.54
CHEMBL2441100 IC50 = 3000.0 nM 5.52
CHEMBL2441091 IC50 = 5900.0 nM 5.23
CHEMBL2441098 IC50 = 6700.0 nM 5.17
CHEMBL2441093 IC50 = 7200.0 nM 5.14
CHEMBL2441105 IC50 = 8800.0 nM 5.06
CHEMBL2441099 IC50 = 8700.0 nM 5.06
CHEMBL2441110 IC50 = 9400.0 nM 5.03
CHEMBL2441097 IC50 = 9700.0 nM 5.01
CHEMBL2441101 IC50 > 10000.0 nM -
CHEMBL2441103 IC50 > 10000.0 nM -
CHEMBL2441102 IC50 > 10000.0 nM -
CHEMBL2441108 IC50 > 10000.0 nM -
CHEMBL2441095 IC50 > 10000.0 nM -
CHEMBL2441109 IC50 > 10000.0 nM -
CHEMBL2441096 IC50 > 10000.0 nM -