Assay Detail
Binding
CHEMBL2446685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.59 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441267 | — | — | 1 | 9.30 |
| CHEMBL2441283 | — | — | 1 | 8.30 |
| CHEMBL2441277 | — | — | 1 | 7.20 |
| CHEMBL2441281 | — | — | 1 | 7.10 |
| CHEMBL2441274 | — | — | 1 | 7.10 |
| CHEMBL2441276 | — | — | 1 | 7.00 |
| CHEMBL2441271 | — | — | 1 | 6.60 |
| CHEMBL2441272 | — | — | 1 | 6.60 |
| CHEMBL2441270 | — | — | 1 | 6.50 |
| CHEMBL2441275 | — | — | 1 | 6.50 |
| CHEMBL2441269 | — | — | 1 | 6.40 |
| CHEMBL2441273 | — | — | 1 | 6.40 |
| CHEMBL2441112 | — | — | 1 | 6.30 |
| CHEMBL2441280 | — | — | 1 | 6.20 |
| CHEMBL2441286 | — | — | 1 | 5.60 |
| CHEMBL2441284 | — | — | 1 | 5.50 |
| CHEMBL2441282 | — | — | 1 | 5.30 |
| CHEMBL2441268 | — | — | 1 | 4.70 |
| CHEMBL2441113 | — | — | 1 | - |
| CHEMBL2441111 | — | — | 1 | - |
| CHEMBL2441285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441267 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL2441283 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2441277 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL2441281 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL2441274 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL2441276 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2441271 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL2441272 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL2441270 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL2441275 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL2441269 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL2441273 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL2441112 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL2441280 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL2441286 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL2441284 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL2441282 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL2441268 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL2441113 | — | Ki | > | 19952.62 | nM | - |
| CHEMBL2441111 | — | Ki | > | 19952.62 | nM | - |
| CHEMBL2441285 | — | Ki | > | 19952.62 | nM | - |