Assay Detail
Functional
CHEMBL2446774
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Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-VIN10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Furanylazaindoles: potent anticancer agents in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.40 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443332 | — | — | 1 | 7.54 |
| CHEMBL2443326 | — | — | 1 | 7.22 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.04 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.91 |
| CHEMBL20684 | ABT-751 | 2.0 | 1 | 6.64 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.78 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443332 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL2443326 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 90.1 | nM | 7.04 |
| CHEMBL107 | COLCHICINE | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL20684 | ABT-751 | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 23000.0 | nM | 4.64 |