Assay Detail
Binding
CHEMBL2447183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant LSD2 (22 to 822 aa) (unknown origin) expressed in Escherichia coli BL21(DE) by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 2 (CHEMBL1938208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.40 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255743 | TRANYLCYPROMINE HYDROCHLORIDE | — | 1 | 4.46 |
| CHEMBL2334501 | — | — | 1 | 4.44 |
| CHEMBL2334497 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255743 | TRANYLCYPROMINE HYDROCHLORIDE | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL2334501 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL2334497 | — | IC50 | = | 49100.0 | nM | 4.31 |