Assay Detail
Binding
CHEMBL2447574
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Displacement of [3H]-prazosin from alpha1 adrenergic receptor in rat cerebral cortex membranes after 50 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.17 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442994 | — | — | 1 | 7.94 |
| CHEMBL522691 | — | — | 1 | 7.65 |
| CHEMBL2442996 | — | — | 1 | 7.52 |
| CHEMBL2442995 | — | — | 1 | 7.42 |
| CHEMBL2442999 | — | — | 1 | 6.71 |
| CHEMBL2442997 | — | — | 1 | 6.53 |
| CHEMBL2442998 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442994 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL522691 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL2442996 | — | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL2442995 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL2442999 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL2442997 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL2442998 | — | Ki | = | 393.0 | nM | 6.41 |