Assay Detail
Binding
CHEMBL2447576
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Displacement of [3H]-8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293-EBNA cells after 120 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.53 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442994 | — | — | 1 | 7.46 |
| CHEMBL2442995 | — | — | 1 | 7.10 |
| CHEMBL2442996 | — | — | 1 | 6.62 |
| CHEMBL2442999 | — | — | 1 | 6.06 |
| CHEMBL2442997 | — | — | 1 | 6.04 |
| CHEMBL2442998 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442994 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2442995 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2442996 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL2442999 | — | Ki | = | 877.0 | nM | 6.06 |
| CHEMBL2442997 | — | Ki | = | 918.0 | nM | 6.04 |
| CHEMBL2442998 | — | Ki | = | 1274.0 | nM | 5.89 |