Assay Detail
ADMET
CHEMBL3047156
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Cytotoxicity against Homo sapiens (human) HEK293 cells after 72 hr by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro anticancer activities of novel aryl-naphthalene lignans
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.12 | 4.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2235106 | — | — | 1 | 4.14 |
| CHEMBL495476 | — | — | 1 | 4.09 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL2235101 | — | — | 1 | - |
| CHEMBL2235100 | — | — | 1 | - |
| CHEMBL2235105 | — | — | 1 | - |
| CHEMBL2235104 | — | — | 1 | - |
| CHEMBL2235103 | — | — | 1 | - |
| CHEMBL2235102 | — | — | 1 | - |
| CHEMBL487214 | DEHYDROPODOPHYLLOTOXIN | — | 1 | - |
| CHEMBL468453 | TAIWANIN E | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2235106 | — | IC50 | = | 72800.0 | nM | 4.14 |
| CHEMBL495476 | — | IC50 | = | 81900.0 | nM | 4.09 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 774400.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 702800.0 | nM | - |
| CHEMBL2235101 | — | IC50 | = | 199500.0 | nM | - |
| CHEMBL2235100 | — | IC50 | = | 301100.0 | nM | - |
| CHEMBL2235105 | — | IC50 | = | 130100.0 | nM | - |
| CHEMBL2235104 | — | IC50 | = | 262100.0 | nM | - |
| CHEMBL2235103 | — | IC50 | = | 272900.0 | nM | - |
| CHEMBL2235102 | — | IC50 | = | 347700.0 | nM | - |
| CHEMBL487214 | DEHYDROPODOPHYLLOTOXIN | IC50 | = | 240000.0 | nM | - |
| CHEMBL468453 | TAIWANIN E | IC50 | = | 523700.0 | nM | - |