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Assay Detail

CHEMBL3052128

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in Rattus norvegicus (rat) uterine membranes
ChEMBL ↗
84
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Predicting 3H-1,2,4-triazolinones as angiotensin II receptor antagonists: 2D and 3D QSAR by kNN-molecular field analysis approach
Parate A, Chaturvedi SC
Med Chem Res (2012) 21 : 1166 -1178
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 7.52 8.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313371 — — 2 8.51
CHEMBL304329 — — 2 8.44
CHEMBL66173 — — 2 8.36
CHEMBL87778 — — 2 8.29
CHEMBL70029 — — 2 8.25
CHEMBL87942 — — 2 8.10
CHEMBL68760 — — 2 8.06
CHEMBL67764 — — 2 8.05
CHEMBL68719 — — 2 8.01
CHEMBL87964 — — 2 8.00
CHEMBL302261 — — 2 7.92
CHEMBL304134 — — 2 7.92
CHEMBL2234571 — — 2 7.82
CHEMBL87669 — — 2 7.82
CHEMBL82797 — — 2 7.82
CHEMBL307310 — — 2 7.80
CHEMBL422593 — — 2 7.80
CHEMBL68731 — — 2 7.77
CHEMBL313222 — — 2 7.75
CHEMBL306882 — — 2 7.75
CHEMBL87985 — — 2 7.70
CHEMBL412664 — — 2 7.68
CHEMBL86084 — — 2 7.66
CHEMBL304600 — — 2 7.66
CHEMBL2234570 — — 2 7.60
CHEMBL2234572 — — 2 7.52
CHEMBL71613 — — 2 7.46
CHEMBL308416 — — 2 7.44
CHEMBL69508 — — 2 7.38
CHEMBL69296 — — 2 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313371 — IC50 = 3.1 nM 8.51
CHEMBL313371 — IC50 = 3.1 nM 8.51
CHEMBL304329 — IC50 = 3.6 nM 8.44
CHEMBL304329 — IC50 = 3.6 nM 8.44
CHEMBL66173 — IC50 = 4.4 nM 8.36
CHEMBL66173 — IC50 = 4.4 nM 8.36
CHEMBL87778 — IC50 = 5.1 nM 8.29
CHEMBL87778 — IC50 = 5.1 nM 8.29
CHEMBL70029 — IC50 = 5.6 nM 8.25
CHEMBL70029 — IC50 = 5.6 nM 8.25
CHEMBL87942 — IC50 = 7.9 nM 8.10
CHEMBL87942 — IC50 = 7.9 nM 8.10
CHEMBL68760 — IC50 = 8.7 nM 8.06
CHEMBL68760 — IC50 = 8.7 nM 8.06
CHEMBL67764 — IC50 = 9.0 nM 8.05
CHEMBL67764 — IC50 = 9.0 nM 8.05
CHEMBL68719 — IC50 = 9.8 nM 8.01
CHEMBL68719 — IC50 = 9.8 nM 8.01
CHEMBL87964 — IC50 = 10.0 nM 8.00
CHEMBL87964 — IC50 = 10.0 nM 8.00
CHEMBL302261 — IC50 = 12.0 nM 7.92
CHEMBL304134 — IC50 = 12.0 nM 7.92
CHEMBL302261 — IC50 = 12.0 nM 7.92
CHEMBL304134 — IC50 = 12.0 nM 7.92
CHEMBL82797 — IC50 = 15.0 nM 7.82
CHEMBL87669 — IC50 = 15.0 nM 7.82
CHEMBL87669 — IC50 = 15.0 nM 7.82
CHEMBL2234571 — IC50 = 15.0 nM 7.82
CHEMBL82797 — IC50 = 15.0 nM 7.82
CHEMBL2234571 — IC50 = 15.0 nM 7.82
CHEMBL422593 — IC50 = 16.0 nM 7.80
CHEMBL422593 — IC50 = 16.0 nM 7.80
CHEMBL307310 — IC50 = 16.0 nM 7.80
CHEMBL307310 — IC50 = 16.0 nM 7.80
CHEMBL68731 — IC50 = 17.0 nM 7.77
CHEMBL68731 — IC50 = 17.0 nM 7.77
CHEMBL313222 — IC50 = 18.0 nM 7.75
CHEMBL306882 — IC50 = 18.0 nM 7.75
CHEMBL306882 — IC50 = 18.0 nM 7.75
CHEMBL313222 — IC50 = 18.0 nM 7.75
CHEMBL87985 — IC50 = 20.0 nM 7.70
CHEMBL87985 — IC50 = 20.0 nM 7.70
CHEMBL412664 — IC50 = 21.0 nM 7.68
CHEMBL412664 — IC50 = 21.0 nM 7.68
CHEMBL86084 — IC50 = 22.0 nM 7.66
CHEMBL304600 — IC50 = 22.0 nM 7.66
CHEMBL86084 — IC50 = 22.0 nM 7.66
CHEMBL304600 — IC50 = 22.0 nM 7.66
CHEMBL2234570 — IC50 = 25.0 nM 7.60
CHEMBL2234570 — IC50 = 25.0 nM 7.60