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Assay Detail

CHEMBL3054040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Canavalia ensiformis (jack bean) urease assessed as inhibition of ammonia production after 15 min by indophenol method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Urease (CHEMBL4161)
Type SINGLE PROTEIN
Organism Canavalia ensiformis

Publication

Synthesis and biological evaluation of some N 4-aryl-substituted 5-fluoroisatin-3-thiosemicarbazones
Pervez H, Saira N, Iqbal MS, Yaqub M, Khan KM
Med Chem Res (2013) 22 : 5878 -5889
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.42 4.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2285981 1 4.69
CHEMBL2285982 1 4.69
CHEMBL2285980 1 4.69
CHEMBL260876 THIOUREA 1 4.68
CHEMBL2285984 1 4.48
CHEMBL2285978 1 4.48
CHEMBL2285990 1 4.42
CHEMBL2285991 1 4.34
CHEMBL2285989 1 4.33
CHEMBL2285979 1 4.32
CHEMBL2285985 1 4.30
CHEMBL2285995 1 4.30
CHEMBL1915702 1 4.30
CHEMBL2285994 1 4.22
CHEMBL2285993 1 4.04
CHEMBL375922 1 -
CHEMBL2285992 1 -
CHEMBL229306 1 -
CHEMBL2285988 1 -
CHEMBL2285987 1 -
CHEMBL2285986 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2285981 IC50 = 20600.0 nM 4.69
CHEMBL2285982 IC50 = 20600.0 nM 4.69
CHEMBL2285980 IC50 = 20600.0 nM 4.69
CHEMBL260876 THIOUREA IC50 = 21000.0 nM 4.68
CHEMBL2285984 IC50 = 33100.0 nM 4.48
CHEMBL2285978 IC50 = 33100.0 nM 4.48
CHEMBL2285990 IC50 = 37700.0 nM 4.42
CHEMBL2285991 IC50 = 45300.0 nM 4.34
CHEMBL2285989 IC50 = 47300.0 nM 4.33
CHEMBL2285979 IC50 = 47600.0 nM 4.32
CHEMBL2285985 IC50 = 50600.0 nM 4.30
CHEMBL2285995 IC50 = 50530.0 nM 4.30
CHEMBL1915702 IC50 = 50600.0 nM 4.30
CHEMBL2285994 IC50 = 59860.0 nM 4.22
CHEMBL2285993 IC50 = 90400.0 nM 4.04
CHEMBL375922 IC50 = 342930.0 nM -
CHEMBL2285992 IC50 - -
CHEMBL229306 IC50 - -
CHEMBL2285988 IC50 - -
CHEMBL2285987 IC50 = 150700.0 nM -
CHEMBL2285986 IC50 - -