Assay Detail
Binding
CHEMBL3055876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as substrate and [gamma32]ATP after 30 min by scinitllation counting
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A 2D image-based approach for modelling some glycogen synthase kinase 3 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.11 | 9.15 |
| Ki | 2 | 7.96 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181031 | BISARYLMALEIMIDE 1 | — | 1 | 9.15 |
| CHEMBL178766 | BISARYLMALEIMIDE 2 | — | 1 | 9.10 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | — | 1 | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | — | 1 | 8.60 |
| CHEMBL427882 | — | — | 1 | 8.40 |
| CHEMBL253769 | INDIRUBIN 1 | — | 1 | 8.40 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 8.40 |
| CHEMBL253770 | INDIRUBIN 2 | — | 1 | 8.30 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | — | 1 | 8.00 |
| CHEMBL299756 | PAULLONE 2 | — | 1 | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 8.00 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | — | 1 | 7.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | — | 1 | 7.77 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | — | 1 | 7.66 |
| CHEMBL102714 | SB-216763 | — | 1 | 7.47 |
| CHEMBL398498 | HYMENIALDISINE 2 | — | 1 | 6.89 |
| CHEMBL7463 | GF-109203 | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181031 | BISARYLMALEIMIDE 1 | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL178766 | BISARYLMALEIMIDE 2 | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL427882 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL253769 | INDIRUBIN 1 | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL253770 | INDIRUBIN 2 | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL299756 | PAULLONE 2 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL102714 | SB-216763 | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL398498 | HYMENIALDISINE 2 | IC50 | = | 128.82 | nM | 6.89 |
| CHEMBL7463 | GF-109203 | IC50 | = | 190.55 | nM | 6.72 |