Compound Detail
CHEMBL66292
PYRAZOLOPYRIMIDINE 2 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL66292 |
| Name | PYRAZOLOPYRIMIDINE 2 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WKJFLAJZSWRICW-FOKLQQMPSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
2.67
ALogP
9
HBA
1
HBD
111.4
PSA (Ų)
0.38
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.6
EC50 1 meas. best 6.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 8.6 | 8.6 | 2.5 | 2 |
| Unchecked CHEMBL612545 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| Glycogen synthase kinase-3 CHEMBL2095188 | EC50 | 6.51 | 6.51 | 310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 2.512 | nM | 8.6 | Ability to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, exp... | 15080992 |
| Glycogen synthase kinase-3 | IC50 | = | 2.512 | nM | 8.6 | Inhibition of glycogen synthase kinase-3 (GSK3-beta) | 15080993 |
| Unchecked | IC50 | = | 2.512 | nM | 8.6 | Inhibition of GSK3 | 17399989 |
| Glycogen synthase kinase-3 beta | IC50 | = | 2.512 | nM | 8.6 | Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as subs... | - |
| Glycogen synthase kinase-3 | EC50 | = | 310.0 | nM | 6.51 | Inhibition of glycogen synthesis in rat skeletal muscle L6 cells | 15080993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| 15080993 | 10.1016/j.bmcl.2004.02.037 | Glycogen synthase kinase-3 | 3 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-4 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase beta-1 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK alpha | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-gamma serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-beta serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase D2 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase D1 | 2 |
Data from ChEMBL 36 via Core Engine