Assay Detail
Functional
CHEMBL709400
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Inhibition of glycogen synthesis in rat skeletal muscle L6 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel GSK-3 inhibitors with improved cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.16 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65944 | — | — | 1 | 6.96 |
| CHEMBL306865 | GW784752X | — | 1 | 6.66 |
| CHEMBL66860 | — | — | 1 | 6.64 |
| CHEMBL69687 | — | — | 1 | 6.62 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | — | 1 | 6.51 |
| CHEMBL63727 | — | — | 1 | 5.91 |
| CHEMBL65988 | — | — | 1 | 5.73 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | — | 1 | 5.63 |
| CHEMBL66072 | — | — | 1 | 5.56 |
| CHEMBL67374 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65944 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL306865 | GW784752X | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL66860 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL69687 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL63727 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL65988 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL66072 | — | EC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL67374 | — | EC50 | = | 4000.0 | nM | 5.40 |