Assay Detail
Binding
CHEMBL686304
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Inhibition of glycogen synthase kinase-3 (GSK3-beta)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel GSK-3 inhibitors with improved cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.93 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | — | 1 | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | — | 1 | 8.60 |
| CHEMBL65944 | — | — | 1 | 8.40 |
| CHEMBL69687 | — | — | 1 | 8.30 |
| CHEMBL66072 | — | — | 1 | 8.30 |
| CHEMBL66860 | — | — | 1 | 8.20 |
| CHEMBL306865 | GW784752X | — | 1 | 8.20 |
| CHEMBL65884 | GW817396X | — | 1 | 8.10 |
| CHEMBL67374 | — | — | 1 | 7.80 |
| CHEMBL66993 | — | — | 1 | 7.70 |
| CHEMBL65988 | — | — | 1 | 7.50 |
| CHEMBL63727 | — | — | 1 | 7.00 |
| CHEMBL303926 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL65944 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL69687 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL66072 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL66860 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL306865 | GW784752X | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL65884 | GW817396X | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL67374 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL66993 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL65988 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL63727 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL303926 | — | IC50 | = | 630.96 | nM | 6.20 |