Assay Detail
Binding
CHEMBL925067
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Inhibition of GSK3
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure based de novo design of novel glycogen synthase kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.09 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181031 | BISARYLMALEIMIDE 1 | — | 1 | 9.15 |
| CHEMBL178766 | BISARYLMALEIMIDE 2 | — | 1 | 9.10 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | — | 1 | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | — | 1 | 8.60 |
| CHEMBL427882 | — | — | 1 | 8.40 |
| CHEMBL253769 | INDIRUBIN 1 | — | 1 | 8.40 |
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 8.40 |
| CHEMBL253770 | INDIRUBIN 2 | — | 1 | 8.30 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | — | 1 | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 8.00 |
| CHEMBL299756 | PAULLONE 2 | — | 1 | 8.00 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | — | 1 | 7.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | — | 1 | 7.77 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | — | 1 | 7.66 |
| CHEMBL102714 | SB-216763 | — | 1 | 7.47 |
| CHEMBL398498 | HYMENIALDISINE 2 | — | 1 | 6.89 |
| CHEMBL7463 | GF-109203 | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181031 | BISARYLMALEIMIDE 1 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL178766 | BISARYLMALEIMIDE 2 | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL304533 | PYRAZOLOPYRIMIDINE 1 | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL66292 | PYRAZOLOPYRIMIDINE 2 | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL427882 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL253769 | INDIRUBIN 1 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL253770 | INDIRUBIN 2 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL299756 | PAULLONE 2 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL102714 | SB-216763 | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL398498 | HYMENIALDISINE 2 | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL7463 | GF-109203 | IC50 | = | 190.0 | nM | 6.72 |