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Assay Detail

CHEMBL3055898

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PTP1B (unknown origin)
ChEMBL ↗
104
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-D QSAR studies of steroidal natural products oleanic acid and their semisynthetic derivatives as potent protein tyrosine phosphatase 1B inhibitors
Joshi P, Tanwar O, Rambhade S, Bhaisare M, Jain D
Med Chem Res (2012) 21 : 351 -361
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 104 5.76 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2262828 — — 2 6.82
CHEMBL2262836 — — 2 6.36
CHEMBL2263115 — — 2 6.35
CHEMBL2263112 — — 2 6.29
CHEMBL2262833 — — 2 6.28
CHEMBL2262834 — — 2 6.28
CHEMBL508831 — — 2 6.27
CHEMBL2263110 — — 2 6.26
CHEMBL2262831 — — 2 6.26
CHEMBL2263111 — — 2 6.25
CHEMBL2263114 — — 2 6.24
CHEMBL2263107 — — 2 6.24
CHEMBL2263109 — — 2 6.23
CHEMBL2262838 — — 2 6.23
CHEMBL2262835 — — 2 6.22
CHEMBL2263113 — — 2 6.21
CHEMBL506556 — — 2 6.21
CHEMBL2262830 — — 2 6.20
CHEMBL2262832 — — 2 6.19
CHEMBL2262837 — — 2 6.18
CHEMBL2263120 — — 2 6.14
CHEMBL2263119 — — 2 6.11
CHEMBL2262829 — — 2 6.09
CHEMBL2263118 — — 2 6.06
CHEMBL2263117 — — 2 5.88
CHEMBL2263116 — — 2 5.68
CHEMBL211369 — — 2 5.63
CHEMBL472896 — — 2 5.58
CHEMBL2262826 — — 2 5.57
CHEMBL2262827 — — 2 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2262828 — IC50 = 150.0 nM 6.82
CHEMBL2262828 — IC50 = 150.0 nM 6.82
CHEMBL2262836 — IC50 = 440.0 nM 6.36
CHEMBL2262836 — IC50 = 440.0 nM 6.36
CHEMBL2263115 — IC50 = 450.0 nM 6.35
CHEMBL2263115 — IC50 = 450.0 nM 6.35
CHEMBL2263112 — IC50 = 510.0 nM 6.29
CHEMBL2263112 — IC50 = 510.0 nM 6.29
CHEMBL2262833 — IC50 = 530.0 nM 6.28
CHEMBL2262834 — IC50 = 520.0 nM 6.28
CHEMBL2262833 — IC50 = 530.0 nM 6.28
CHEMBL2262834 — IC50 = 520.0 nM 6.28
CHEMBL508831 — IC50 = 540.0 nM 6.27
CHEMBL508831 — IC50 = 540.0 nM 6.27
CHEMBL2262831 — IC50 = 550.0 nM 6.26
CHEMBL2263110 — IC50 = 550.0 nM 6.26
CHEMBL2263110 — IC50 = 550.0 nM 6.26
CHEMBL2262831 — IC50 = 550.0 nM 6.26
CHEMBL2263111 — IC50 = 560.0 nM 6.25
CHEMBL2263111 — IC50 = 560.0 nM 6.25
CHEMBL2263114 — IC50 = 570.0 nM 6.24
CHEMBL2263114 — IC50 = 570.0 nM 6.24
CHEMBL2263107 — IC50 = 570.0 nM 6.24
CHEMBL2263107 — IC50 = 570.0 nM 6.24
CHEMBL2263109 — IC50 = 590.0 nM 6.23
CHEMBL2262838 — IC50 = 590.0 nM 6.23
CHEMBL2263109 — IC50 = 590.0 nM 6.23
CHEMBL2262838 — IC50 = 590.0 nM 6.23
CHEMBL2262835 — IC50 = 600.0 nM 6.22
CHEMBL2262835 — IC50 = 600.0 nM 6.22
CHEMBL506556 — IC50 = 620.0 nM 6.21
CHEMBL2263113 — IC50 = 610.0 nM 6.21
CHEMBL2263113 — IC50 = 610.0 nM 6.21
CHEMBL506556 — IC50 = 620.0 nM 6.21
CHEMBL2262830 — IC50 = 630.0 nM 6.20
CHEMBL2262830 — IC50 = 630.0 nM 6.20
CHEMBL2262832 — IC50 = 650.0 nM 6.19
CHEMBL2262832 — IC50 = 650.0 nM 6.19
CHEMBL2262837 — IC50 = 660.0 nM 6.18
CHEMBL2262837 — IC50 = 660.0 nM 6.18
CHEMBL2263120 — IC50 = 720.0 nM 6.14
CHEMBL2263120 — IC50 = 720.0 nM 6.14
CHEMBL2263119 — IC50 = 780.0 nM 6.11
CHEMBL2263119 — IC50 = 780.0 nM 6.11
CHEMBL2262829 — IC50 = 820.0 nM 6.09
CHEMBL2262829 — IC50 = 820.0 nM 6.09
CHEMBL2263118 — IC50 = 880.0 nM 6.06
CHEMBL2263118 — IC50 = 880.0 nM 6.06
CHEMBL2263117 — IC50 = 1330.0 nM 5.88
CHEMBL2263117 — IC50 = 1330.0 nM 5.88