Assay Detail
Binding
CHEMBL3060413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bos taurus (bovine) mitochondrial complex 1 assessed as reduction in enzyme activity by NADH-HU oxidoreductase assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NADH-ubiquinone oxidoreductase chain 1 (CHEMBL4497) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Hybrid ubiquinone: novel inhibitor of mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272733 | PIERICIDIN A | — | 1 | 8.52 |
| CHEMBL2272021 | — | — | 1 | 7.11 |
| CHEMBL2272023 | — | — | 1 | 6.47 |
| CHEMBL2272022 | — | — | 1 | 6.43 |
| CHEMBL2272026 | — | — | 1 | 6.33 |
| CHEMBL2272029 | — | — | 1 | 6.19 |
| CHEMBL2272025 | — | — | 1 | 6.01 |
| CHEMBL2272027 | — | — | 1 | 5.96 |
| CHEMBL2272024 | — | — | 1 | 5.75 |
| CHEMBL2272028 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272733 | PIERICIDIN A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2272021 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2272023 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2272022 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2272026 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2272029 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2272025 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2272027 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2272024 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2272028 | — | IC50 | = | 11800.0 | nM | 4.93 |