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Assay Detail

CHEMBL3063098

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PKCbeta2 (unknown origin)
ChEMBL ↗
79
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein kinase C beta type (CHEMBL3045) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2D and 3D QSAR analyses to predict favorable substitution sites in anilino-monoindolylmaleimides acting as PKCII selective inhibitors
Sri Divya P, Grewal BK, Elizabeth Sobhia M
Med Chem Res (2011) 20 : 1188 -1199
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 79 7.58 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2236794 — — 2 8.85
CHEMBL540357 — — 2 8.70
CHEMBL2236799 — — 2 8.70
CHEMBL2236809 — — 2 8.66
CHEMBL2236793 — — 2 8.62
CHEMBL2236802 — — 2 8.40
CHEMBL2236804 — — 2 8.40
CHEMBL2236805 — — 2 8.40
CHEMBL366266 — — 2 8.30
CHEMBL2236807 — — 2 8.30
CHEMBL2236798 — — 2 8.22
CHEMBL2236803 — — 2 8.22
CHEMBL2236795 — — 2 8.10
CHEMBL2236797 — — 2 8.10
CHEMBL2236808 — — 2 8.10
CHEMBL364337 — — 2 8.00
CHEMBL365656 — — 2 7.92
CHEMBL2236796 — — 2 7.85
CHEMBL369114 — — 2 7.82
CHEMBL184548 — — 2 7.82
CHEMBL187235 — — 2 7.77
CHEMBL2236800 — — 2 7.77
CHEMBL184042 — — 2 7.75
CHEMBL184146 — — 2 7.64
CHEMBL2236801 — — 2 7.60
CHEMBL184649 — — 2 7.55
CHEMBL185221 — — 2 7.52
CHEMBL2236806 — — 2 7.50
CHEMBL184647 — — 2 7.39
CHEMBL185573 — — 2 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2236794 — IC50 = 1.4 nM 8.85
CHEMBL2236794 — IC50 = 1.413 nM 8.85
CHEMBL2236799 — IC50 = 2.0 nM 8.70
CHEMBL540357 — IC50 = 2.0 nM 8.70
CHEMBL540357 — IC50 = 2.042 nM 8.69
CHEMBL2236799 — IC50 = 2.042 nM 8.69
CHEMBL2236809 — IC50 = 2.2 nM 8.66
CHEMBL2236809 — IC50 = 2.239 nM 8.65
CHEMBL2236793 — IC50 = 2.4 nM 8.62
CHEMBL2236793 — IC50 = 2.455 nM 8.61
CHEMBL2236804 — IC50 = 4.0 nM 8.40
CHEMBL2236805 — IC50 = 4.0 nM 8.40
CHEMBL2236802 — IC50 = 4.0 nM 8.40
CHEMBL2236804 — IC50 = 4.074 nM 8.39
CHEMBL2236805 — IC50 = 4.074 nM 8.39
CHEMBL2236802 — IC50 = 4.074 nM 8.39
CHEMBL366266 — IC50 = 5.012 nM 8.30
CHEMBL366266 — IC50 = 5.0 nM 8.30
CHEMBL2236807 — IC50 = 5.012 nM 8.30
CHEMBL2236807 — IC50 = 5.0 nM 8.30
CHEMBL2236798 — IC50 = 6.0 nM 8.22
CHEMBL2236803 — IC50 = 6.0 nM 8.22
CHEMBL2236798 — IC50 = 6.026 nM 8.22
CHEMBL2236803 — IC50 = 6.026 nM 8.22
CHEMBL2236797 — IC50 = 8.0 nM 8.10
CHEMBL2236808 — IC50 = 8.0 nM 8.10
CHEMBL2236795 — IC50 = 7.943 nM 8.10
CHEMBL2236795 — IC50 = 7.9 nM 8.10
CHEMBL2236797 — IC50 = 8.128 nM 8.09
CHEMBL2236808 — IC50 = 8.128 nM 8.09
CHEMBL364337 — IC50 = 10.0 nM 8.00
CHEMBL364337 — IC50 = 10.0 nM 8.00
CHEMBL365656 — IC50 = 12.02 nM 7.92
CHEMBL365656 — IC50 = 12.0 nM 7.92
CHEMBL2236796 — IC50 = 14.0 nM 7.85
CHEMBL2236796 — IC50 = 14.13 nM 7.85
CHEMBL184548 — IC50 = 15.0 nM 7.82
CHEMBL369114 — IC50 = 15.14 nM 7.82
CHEMBL369114 — IC50 = 15.0 nM 7.82
CHEMBL184548 — IC50 = 15.14 nM 7.82
CHEMBL2236800 — IC50 = 17.0 nM 7.77
CHEMBL187235 — IC50 = 17.0 nM 7.77
CHEMBL2236800 — IC50 = 17.38 nM 7.76
CHEMBL187235 — IC50 = 17.38 nM 7.76
CHEMBL184042 — IC50 = 18.0 nM 7.75
CHEMBL184042 — IC50 = 18.2 nM 7.74
CHEMBL184146 — IC50 = 23.0 nM 7.64
CHEMBL184146 — IC50 = 23.44 nM 7.63
CHEMBL2236801 — IC50 = 25.12 nM 7.60
CHEMBL2236801 — IC50 = 25.0 nM 7.60