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Assay Detail

CHEMBL3063284

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Binding
Inhibition of Plasmodium falciparum W2
ChEMBL ↗
84
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Molecular modeling studies of some substituted chalcone derivatives as cysteine protease inhibitors
Sahu NK, Bari SB, Kohli DV
Med Chem Res (2012) 21 : 3835 -3847
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 5.63 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2237711 — — 2 6.64
CHEMBL2237687 — — 2 6.44
CHEMBL2237688 — — 2 6.29
CHEMBL2237689 — — 2 6.15
CHEMBL2237690 — — 2 6.12
CHEMBL58557 — — 2 6.12
CHEMBL2237691 — — 2 6.11
CHEMBL2237692 — — 2 6.10
CHEMBL146192 — — 2 6.05
CHEMBL2237695 — — 2 6.04
CHEMBL2237694 — — 2 6.00
CHEMBL2237693 — — 2 6.00
CHEMBL2237696 — — 2 5.94
CHEMBL570849 — — 2 5.93
CHEMBL2237697 — — 2 5.86
CHEMBL2237707 — — 2 5.85
CHEMBL2237705 — — 2 5.77
CHEMBL142854 — — 2 5.72
CHEMBL2237698 — — 2 5.68
CHEMBL2237708 — — 2 5.64
CHEMBL146137 — — 2 5.61
CHEMBL2237706 — — 2 5.57
CHEMBL2237913 — — 2 5.55
CHEMBL2237914 — — 2 5.51
CHEMBL2237710 — — 2 5.50
CHEMBL1946993 — — 2 5.48
CHEMBL138184 — — 2 5.42
CHEMBL2237709 — — 2 5.41
CHEMBL2237700 — — 2 5.37
CHEMBL2237912 — — 2 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2237711 — IC50 = 230.14 nM 6.64
CHEMBL2237711 — IC50 = 230.0 nM 6.64
CHEMBL2237687 — IC50 = 359.75 nM 6.44
CHEMBL2237687 — IC50 = 360.0 nM 6.44
CHEMBL2237688 — IC50 = 510.0 nM 6.29
CHEMBL2237688 — IC50 = 510.5 nM 6.29
CHEMBL2237689 — IC50 = 710.0 nM 6.15
CHEMBL2237689 — IC50 = 709.58 nM 6.15
CHEMBL2237690 — IC50 = 750.0 nM 6.12
CHEMBL58557 — IC50 = 750.0 nM 6.12
CHEMBL58557 — IC50 = 749.89 nM 6.12
CHEMBL2237690 — IC50 = 749.89 nM 6.12
CHEMBL2237691 — IC50 = 769.13 nM 6.11
CHEMBL2237691 — IC50 = 770.0 nM 6.11
CHEMBL2237692 — IC50 = 799.83 nM 6.10
CHEMBL2237692 — IC50 = 800.0 nM 6.10
CHEMBL146192 — IC50 = 899.5 nM 6.05
CHEMBL146192 — IC50 = 900.0 nM 6.05
CHEMBL2237695 — IC50 = 920.45 nM 6.04
CHEMBL2237695 — IC50 = 920.0 nM 6.04
CHEMBL2237694 — IC50 = 1000.0 nM 6.00
CHEMBL2237693 — IC50 = 1000.0 nM 6.00
CHEMBL2237694 — IC50 = 1000.0 nM 6.00
CHEMBL2237693 — IC50 = 1000.0 nM 6.00
CHEMBL2237696 — IC50 = 1140.0 nM 5.94
CHEMBL2237696 — IC50 = 1140.25 nM 5.94
CHEMBL570849 — IC50 = 1180.32 nM 5.93
CHEMBL570849 — IC50 = 1180.0 nM 5.93
CHEMBL2237697 — IC50 = 1380.38 nM 5.86
CHEMBL2237697 — IC50 = 1380.0 nM 5.86
CHEMBL2237707 — IC50 = 1400.0 nM 5.85
CHEMBL2237707 — IC50 = 1399.59 nM 5.85
CHEMBL2237705 — IC50 = 1698.24 nM 5.77
CHEMBL2237705 — IC50 = 1700.0 nM 5.77
CHEMBL142854 — IC50 = 1900.0 nM 5.72
CHEMBL142854 — IC50 = 1901.08 nM 5.72
CHEMBL2237698 — IC50 = 2090.0 nM 5.68
CHEMBL2237698 — IC50 = 2089.3 nM 5.68
CHEMBL2237708 — IC50 = 2300.0 nM 5.64
CHEMBL2237708 — IC50 = 2301.44 nM 5.64
CHEMBL146137 — IC50 = 2460.0 nM 5.61
CHEMBL146137 — IC50 = 2460.37 nM 5.61
CHEMBL2237706 — IC50 = 2697.74 nM 5.57
CHEMBL2237706 — IC50 = 2700.0 nM 5.57
CHEMBL2237913 — IC50 = 2800.0 nM 5.55
CHEMBL2237913 — IC50 = 2798.98 nM 5.55
CHEMBL2237914 — IC50 = 3097.42 nM 5.51
CHEMBL2237914 — IC50 = 3100.0 nM 5.51
CHEMBL2237710 — IC50 = 3200.0 nM 5.50
CHEMBL2237710 — IC50 = 3198.9 nM 5.50