Compound Detail
CHEMBL146137
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL146137 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BUOFZASIAIOVHV-DHZHZOJOSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
351.2
MW (Da)
5.30
ALogP
3
HBA
0
HBD
35.5
PSA (Ų)
0.54
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.61 | 5.5075 | 2460.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 2460.0 | nM | 5.61 | In vitro antimalarial activity against chloroquine-resistant Plasmodium falcipar... | 8544179 |
| Plasmodium falciparum | IC50 | = | 2460.37 | nM | 5.61 | Inhibition of Plasmodium falciparum W2 | - |
| Plasmodium falciparum | IC50 | = | 2460.0 | nM | 5.61 | Inhibition of Plasmodium falciparum W2 | - |
| Plasmodium falciparum | IC50 | = | 6260.0 | nM | 5.2 | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falcipar... | 8544179 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8544179 | 10.1021/jm00026a010 | Plasmodium falciparum | 2 |
| - | 10.1007/s00044-011-9900-1 | Plasmodium falciparum | 2 |
| 8544179 | 10.1021/jm00026a010 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine